Alzheimer’s Antibody Research: New Breakthroughs and Old Problems

Antibody Rendering (Credit: Image courtesy of Rensselaer Polytechnic Institute) recently post this article about the development of an Alzheimer’s antibody. According to Assistant Professor of Chemical and Biological Engineering Peter Tessier and his colleagues at Rensselaer Polytechnic Institute and with funding from the Alzheimer’s Association, the National Science Foundation (NSF), and the Pew Charitable Trust, a new method for designing antibodies in a “surprisingly simple” way has produced some promising results.

Using antibodies to attack and eliminate offending proteins, like APoE4, is nothing new and the buzz around this type of treatment did not appear without promising initial results. However, upon further trials, some of the early attempts have resulted in only “okay” results often due to dangerous side effects like brain swelling.

So whats the big deal? Well, it seems that the ability to easily design antibodies is the breakthrough here. Easier methods for designing antibodies may mean more designs, and more deigns may mean that researchers will be able to eventually create more targeted antibodies. In the case of the “Rensselaer” study, the most promising antibody developed using the new method only attacks the toxic, sticky “Alzheimer’s protein” rather than the building blocks of the Alzheimer’s protein.

Read the original article by clicking below and check out the other links below for a bit of background on antibody treatment for Alzheimer’s:

Researchers design Alzheimer’s antibodies: Surprisingly simple method to target harmful proteins.


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